1,231 research outputs found
Grain Destruction in Interstellar Shocks
Interstellar shock waves can erode and destroy grains present in the shocked
gas, primarily as the result of sputtering and grain-grain collisions.
Uncertainties in current estimates of sputtering yields are reviewed. Results
are presented for the simple case of sputtering of fast grains being stopped in
cold gas. An upper limit is derived for sputtering of refractory grains in
C-type MHD shocks: shock speeds v_s \gtrsim 50 \kms are required for return
of more than 30\% of the silicate to the gas phase. Sputtering can also be
important for removing molecular ice mantles from grains in two-fluid MHD shock
waves in molecular gas. Recent estimates of refractory grain lifetimes against
destruction in shock waves are summarized, and the implications of these short
lifetimes are discussed.Comment: To appear in Shocks in Astrophysics, ed. T.J. Millar. Talk given at
conference Shocks in Astrophysics, Manchester, Jan. 1995. 13 pages with 6
figures: uuencoded compressed postscript. Also available as POPe-633 on
http://astro.princeton.edu/~library/prep.htm
Comparing antibody responses to Onchocerca volvulus and non-parasite antigens in placebo-controlled and ivermectin-treated onchocerciasis patients
Serum antibodies to parasite-specific and non-parasite antigens were evaluated using enzyme-linked immunosorbent assay (ELISA). Out of the 470 sera collected, 409 were from residents of an onchocerciasis hyper-endemic area, 55 non-endemic and 6 European normal sera served as control. The patientsâ age, sex, skin microfilaria densities, dermal and ocular clinical manifestations (colour of optic disc) have been well characterised. The study population had participated in a placebocontrolled (n=191) trial of ivermectin (MectizanÂź) treatment (n=218). The parasite antigens are phosphate buffered saline crude extract of adult worms of Onchocerca volvulus, a recombinant antigen (Ov1.9) and a monoclonal antibody purified antigen (Cam 1). The non-parasite antigens are deoxycholate citrate extract of optic nerve (nerve-DOC) and commercially available IgA, IgM and IgG were used to assay for rheumatoid factor (Rh-F) auto-antibodies. Generally, antibodies to parasite antigens in onchocerciasis patients were remarkably higher than control group (p<0.05) using exact F-test. There was no significant difference (p>0.05) in antibodies to nerve-DOC and Rh-F in patients compared to control. Antibodies increased with increasing skin snip microfilaria load from 0.69±0.28 with 0mf/mg (n=54) as against 0.80±0.26 for those with 4-20mf/mg. Observed slight negative correlation in IgG antibody levels and severity of disc colour with mean OD values of 0.26±0.22 in those graded as having no optic nerve disease (OND) (disc 1, n=86) and 0.17±0.19 for those with severe changes (disc 3, n=49) was not statistically significant (P>0.05). An age dependent significant decrease (P<0.05) in antibodies were observed with 0.64±0.34 for 15-30yr old (n=48) compared to 0.48±0.35 for those 50yr (n=50) for PBS with a similar trend for IgG to Ov1.9 and Cam1. In conclusion, serum parasite-specific and non-parasite antibodies may not be responsible for the pathology of optic nerve disease. Onchocerciasis patients were apparently not at higher risk of developing rheumatoid arthritis than the control.Keywords: Onchocerciasis; Antibodies; Antigens; Immune responses; Ivermectin
Abrupt episode of mid-Cretaceous ocean acidification triggered by massive volcanism
Large igneous province volcanic activity during the mid-Cretaceous approximately 94.5 million years ago triggered a global-scale episode of reduced marine oxygen levels known as Oceanic Anoxic Event 2. It has been hypothesized that this geologically rapid degassing of volcanic carbon dioxide altered seawater carbonate chemistry, affecting marine ecosystems, geochemical cycles, and sedimentation. Here, we report on two sites drilled by the International Ocean Discovery Program offshore of southwest Australia that exhibit clear evidence for suppressed pelagic carbonate sedimentation in the form of a stratigraphic interval barren of carbonate, recording ocean acidification during the event. We then use the osmium isotopic composition of bulk sediments to directly link this protracted ~600- kiloyear shoaling of the marine calcite compensation depth to the onset of volcanic activity. This decrease in marine pH was prolonged by biogeochemical feedbacks in highly productive regions that elevated heterotrophic respiration of carbon dioxide to the water column. A compilation of mid- Cretaceous marine stratigraphic records reveals a contemporaneous decrease of sedimentary carbonate content at continental slope sites globally. Thus, we contend that changes in marine carbonate chemistry are a primary ecological stress and important consequence of rapid emission of carbon dioxide during many large igneous province eruptions in the geologic past
Formation of Small-Scale Condensations in the Molecular Clouds via Thermal Instability
A systematic study of the linear thermal instability of a self-gravitating
magnetic molecular cloud is carried out for the case when the unperturbed
background is subject to local expansion or contraction. We consider the
ambipolar diffusion, or ion-neutral friction on the perturbed states. In this
way, we obtain a non-dimensional characteristic equation that reduces to the
prior characteristic equation in the non-gravitating stationary background. By
parametric manipulation of this characteristic equation, we conclude that there
are, not only oblate condensation forming solutions, but also prolate solutions
according to local expansion or contraction of the background. We obtain the
conditions for existence of the Field lengths that thermal instability in the
molecular clouds can occur. If these conditions establish, small-scale
condensations in the form of spherical, oblate, or prolate may be produced via
thermal instability.Comment: 16 page, accepted by Ap&S
SPIDER: Probing the Early Universe with a Suborbital Polarimeter
We evaluate the ability of SPIDER, a balloon-borne polarimeter, to detect a
divergence-free polarization pattern ("B-modes") in the Cosmic Microwave
Background (CMB). In the inflationary scenario, the amplitude of this signal is
proportional to that of the primordial scalar perturbations through the
tensor-to-scalar ratio r. We show that the expected level of systematic error
in the SPIDER instrument is significantly below the amplitude of an interesting
cosmological signal with r=0.03. We present a scanning strategy that enables us
to minimize uncertainty in the reconstruction of the Stokes parameters used to
characterize the CMB, while accessing a relatively wide range of angular
scales. Evaluating the amplitude of the polarized Galactic emission in the
SPIDER field, we conclude that the polarized emission from interstellar dust is
as bright or brighter than the cosmological signal at all SPIDER frequencies
(90 GHz, 150 GHz, and 280 GHz), a situation similar to that found in the
"Southern Hole." We show that two ~20-day flights of the SPIDER instrument can
constrain the amplitude of the B-mode signal to r<0.03 (99% CL) even when
foreground contamination is taken into account. In the absence of foregrounds,
the same limit can be reached after one 20-day flight.Comment: 29 pages, 8 figures, 4 tables; v2: matches published version, flight
schedule updated, two typos fixed in Table 2, references and minor
clarifications added, results unchange
Threshold Electrodisintegration of ^3He
Cross sections were measured for the near-threshold electrodisintegration of
^3He at momentum transfer values of q=2.4, 4.4, and 4.7 fm^{-1}. From these and
prior measurements the transverse and longitudinal response functions R_T and
R_L were deduced. Comparisons are made against previously published and new
non-relativistic A=3 calculations using the best available NN potentials. In
general, for q<2 fm^{-1} these calculations accurately predict the threshold
electrodisintegration of ^3He. Agreement at increasing q demands consideration
of two-body terms, but discrepancies still appear at the highest momentum
transfers probed, perhaps due to the neglect of relativistic dynamics, or to
the underestimation of high-momentum wave-function components.Comment: 9 pages, 7 figures, 1 table, REVTEX4, submitted to Physical Review
Design, development and verification of the 30 and 44 GHz front-end modules for the Planck Low Frequency Instrument
We give a description of the design, construction and testing of the 30 and
44 GHz Front End Modules (FEMs) for the Low Frequency Instrument (LFI) of the
Planck mission to be launched in 2009. The scientific requirements of the
mission determine the performance parameters to be met by the FEMs, including
their linear polarization characteristics.
The FEM design is that of a differential pseudo-correlation radiometer in
which the signal from the sky is compared with a 4-K blackbody load. The Low
Noise Amplifier (LNA) at the heart of the FEM is based on indium phosphide High
Electron Mobility Transistors (HEMTs). The radiometer incorporates a novel
phase-switch design which gives excellent amplitude and phase match across the
band.
The noise temperature requirements are met within the measurement errors at
the two frequencies. For the most sensitive LNAs, the noise temperature at the
band centre is 3 and 5 times the quantum limit at 30 and 44 GHz respectively.
For some of the FEMs, the noise temperature is still falling as the ambient
temperature is reduced to 20 K. Stability tests of the FEMs, including a
measurement of the 1/f knee frequency, also meet mission requirements.
The 30 and 44 GHz FEMs have met or bettered the mission requirements in all
critical aspects. The most sensitive LNAs have reached new limits of noise
temperature for HEMTs at their band centres. The FEMs have well-defined linear
polarization characteristcs.Comment: 39 pages, 33 figures (33 EPS files), 12 tables. Planck LFI technical
papers published by JINST:
http://www.iop.org/EJ/journal/-page=extra.proc5/1748-022
The Magnificent Seven: Magnetic fields and surface temperature distributions
Presently seven nearby radio-quiet isolated neutron stars discovered in ROSAT
data and characterized by thermal X-ray spectra are known. They exhibit very
similar properties and despite intensive searches their number remained
constant since 2001 which led to their name ``The Magnificent Seven''. Five of
the stars exhibit pulsations in their X-ray flux with periods in the range of
3.4 s to 11.4 s. XMM-Newton observations revealed broad absorption lines in the
X-ray spectra which are interpreted as cyclotron resonance absorption lines by
protons or heavy ions and / or atomic transitions shifted to X-ray energies by
strong magnetic fields of the order of 10^13 G. New XMM-Newton observations
indicate more complex X-ray spectra with multiple absorption lines. Pulse-phase
spectroscopy of the best studied pulsars RX J0720.4-3125 and RBS 1223 reveals
variations in derived emission temperature and absorption line depth with pulse
phase. Moreover, RX J0720.4-3125 shows long-term spectral changes which are
interpreted as due to free precession of the neutron star. Modeling of the
pulse profiles of RX J0720.4-3125 and RBS 1223 provides information about the
surface temperature distribution of the neutron stars indicating hot polar caps
which have different temperatures, different sizes and are probably not located
in antipodal positions.Comment: 10 pages, 8 figures, to appear in Astrophysics and Space Science, in
the proceedings of "Isolated Neutron Stars: from the Interior to the
Surface", edited by D. Page, R. Turolla and S. Zan
CLK1/CLK2 driven signalling at the Leishmania kinetochore is captured by spatially referenced proximity phosphoproteomics
Kinetochores in the parasite Leishmania and related kinetoplastids appear to be unique amongst eukaryotes and contain protein kinases as core components. Using the kinetochore kinases KKT2, KKT3 and CLK2 as baits, we developed a BirA* proximity biotinylation methodology optimised for sensitivity, XL-BioID, to investigate the composition and function of the Leishmania kinetochore. We could detect many of the predicted components and also discovered two novel kinetochore proteins, KKT24 and KKT26. Using KKT3 tagged with a fast-acting promiscuous biotin ligase variant, we took proximity biotinylation snapshots of the kinetochore in synchronised parasites. To quantify proximal phosphosites at the kinetochore as the parasite progressed through the cell cycle, we further developed a spatially referenced proximity phosphoproteomics approach. This revealed a group of phosphosites at the kinetochore that were highly dynamic during kinetochore assembly. We show that the kinase inhibitor AB1 targets CLK1/CLK2 (KKT10/KKT19) in Leishmania leading to defective cytokinesis. Using AB1 to uncover CLK1/CLK2 driven signalling pathways important for kinetochore function at G2/M, we found a set of 16 inhibitor responsive kinetochore-proximal phosphosites. Our results exploit new proximity labelling approaches to provide a direct analysis of the Leishmania kinetochore, which is emerging as a promising drug target
- âŠ